The statements, opinions and data contained in the journals are solely 3. DNA damages by X rays as well as heavy ions are induced by a combination of direct and indirect actions.
The result of indirect action of radiation on DNA molecules is the impairment of function or death of the cell. and A.M.; investigation, A.M., I.D.
Direct and Indirect Ionizing Radiation Photons and particles with sufficient energy have the ability to liberate orbital electrons from atoms and their corresponding molecules.
Received: 24 April 2020 / Revised: 8 May 2020 / Accepted: 11 May 2020 / Published: 14 May 2020 This functionality is provided solely for your convenience and is in no way intended to replace human translation. Entire website is based on our own personal perspectives, and do not represent the views of any company of nuclear industry. Publication Date: Mon Jan 15 00:00:00 EST 1951 Research Org.
[The parametrization for the fraction of indirect damage quenched by DMSO (The extension of our approach introduced here, which includes the effect of hypoxia, results in excellent predictions of the experimental survival data over a range of DMSO concentration at three different dose levels each for two different cell lines (In conclusion, we could demonstrate, that we can introduce a simple mechanistic differentiation of direct and indirect action into our existing model and accurately predict cell survival for different levels of free radicals reduction via DMSO.
Please note that many of the page functionalities won't work as expected without javascript enabled. ; resources, J.D. The nerve and muscle cells are the slowest to regenerate and are the least sensitive cells.If a person is irradiated only partially, the dose will depend strongly on the tissue, which was irradiated.
This results in the production of free radicals, which are
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K. B. DAWSON 1, E. O. Clinical Cooperation Unit Radiation Oncology, German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyDivision of Molecular and Translational Radiation Oncology, National Center for Tumor Diseases (NCT), Heidelberg University Hospital, 69120 Heidelberg, GermanyHeidelberg Institute of Radiation Oncology (HIRO), German Cancer Research Center (DKFZ), 69120 Heidelberg, GermanyGerman Cancer Consortium (DKTK), 69120 Heidelberg, GermanyHeidelberg Ion-Beam Therapy Center (HIT), 69120 Heidelberg, GermanyFaculty of Physics and Astronomy, Heidelberg University, 69120 Heidelberg, GermanyAuthor to whom correspondence should be addressed. Please let us know what you think of our products and services.
[The modeling approach of the basic model has been extensively described and discussed in previous publications [In previous works it was shown that in our model a change in oxygenation solely leads to a reduction of the DSB yield, by a hypoxia reduction factor (In our extension of this model for this work, we introduced a distinction of direct and indirect (radical-mediated) DSB induction rate.
Copyright 2020 Nuclear Power for Everybody | All Rights Reserved | Powered by Relat. Using linear non-threshold model (LNT), possible risks from exposure to low dose ionizing radiation (below 100 mSv) are estimated by extrapolating from data obtained after exposure to higher doses of radiation. Therefore, it is nowadays accepted that the detrimental effects of ionizing radiation are not restricted only in the irradiated cells, but also to non-irradiated bystander or even distant cells manifesting various biological effects.Peer review under responsibility of The Egyptian Society of Radiation Sciences and Applications.We use cookies to help provide and enhance our service and tailor content and ads.
If a purified virus preparation is irradiated at high dilution, however, an indirect effec its found.
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